Cerebrovascular segmentation from MRA images

There is provided a method of processing a cerebrovascular medical image, the method comprising receiving magnetic resonance angiography (MRA) image associated with a cerebrovascular tissue comprising blood vessels and brain tissues other than blood vessels; segmenting MRA image using a prior appearance model for generating first prior appearance features representing a first-order prior appearance model and second appearance features representing a second-order prior appearance model of the cerebrovascular tissue, wherein current appearance model comprises a 3D Markov-Gibbs Random Field (MGRF) having a 2D rotational and translational symmetry such that MGRF model is 2D rotation and translation invariant; segmenting MRA image using current appearance model for generating current appearance features distinguishing blood vessels from other brain tissues; adjusting MRA image using first and second prior appearance features and current appearance futures; and generating an enhanced MRA image based on said adjustment. There is also provided a system for doing the same. Application US16/159,790 events 2018-10-15 Application filed by Zayed University 2018-10-15 Priority to US16/159,790 2018-10-15 Assigned to Zayed University 2020-04-16 Publication of US20200116808A1 2020-09-08 Application granted 2020-09-08 Publication of US10768259B2 Status Active 2039-03-02 Adjusted expiratio

Laws of Conservation as Related to Brain Growth, Aging, and Evolution: Symmetry of the Minicolumn

Development, aging, and evolution offer different time scales regarding possible anatomical transformations of the brain. This article expands on the perspective that the cerebral cortex exhibits a modular architecture with invariant properties in regards to these time scales. These properties arise from morphometric relations of the ontogenetic minicolumn as expressed in Noether’s first theorem, i.e., that for each continuous symmetry there is a conserved quantity. Whenever minicolumnar symmetry is disturbed by either developmental or aging processes the principle of least action limits the scope of morphometric alterations. Alternatively, local and global divergences from these laws apply to acquired processes when the system is no longer isolated from its environment. The underlying precepts to these physical laws can be expressed in terms of mathematical equations that are conservative of quantity. Invariant properties of the brain include the rotational symmetry of minicolumns, a scaling proportion or “even expansion” between pyramidal cells and core minicolumnar size, and the translation of neuronal elements from the main axis of the minicolumn. It is our belief that a significant portion of the architectural complexity of the cerebral cortex, its response to injury, and its evolutionary transformation, can all be captured by a small set of basic physical laws dictated by the symmetry of minicolumns. The putative preservations of parameters related to the symmetry of the minicolumn suggest that the development and final organization of the cortex follows a deterministic process

A Review on the Cerebrovascular Segmentation Methods

© 2018 IEEE. This paper explores various methods that have been proposed for the segmentation of the cerebrovascular structure. All of the methods listed are a combination old, new, automatic and semiautomatic models that produce promising results. Each method will be explained along with its advantages and disadvantages. Each of the methods explained are further explored in this paper with variety algorithms produced by using certain models to target certain areas in the cerebrovascular structure. These algorithms were developed to segment cerebrovascular structures from scans obtained from various image modalities e.g., time of flight magnetic-resonance angiography (TOF-MRA), and computed tomography angiography (CTA)

Early Diagnosis and Staging of Prostate Cancer Using Magnetic Resonance Imaging: State of the Art and Perspectives

Prostate cancer is the second most common cancer among men in the United States after skin cancer. Although it can be a serious disease, early diagnosis of prostate cancer can significantly prevent the growth of cancerous cells. The feature extraction is the process of defining and deriving from the prostate region computational entities that form a sort of prostate cancer signature. Full computer-aided diagnosis (CAD) systems presented in several studies have reported the use of engineered features obtained from multimodal magnetic resonance imaging (MRI) to detect prostate cancer. Similar to other medical imaging CAD systems, the computer-aided diagnosis of prostate cancer using MRI framework encompasses four stages, namely: pre-processing, prostate region extraction, features extraction, and classification. Identifying the region of interest in the MR images is essential to reduce the complexity of the next stages and enhance the performance of the overall CAD system

Medical image analysis for the early prediction of hypertension

Recently, medical image analysis has become a vital evolving technology that is used in the early diagnosis of various diseases. Medical imaging techniques enable physicians to capture noninvasive images of structures inside the human body (such as bones, tissues, or blood vessels) as well as their functions (such as brain activity). In this study, magnetic resonance angiography (MRA) images have been analyzed to help physicians in the early prediction of hypertension. Hypertension is a progressive disease that may take several years before being fully understood. In the United States, hypertension afflicts one in every three adults and is a leading cause of mortality in more than half a million patients every year. Specific alterations in human brains’ cerebrovasculature have been observed to precede the onset of hypertension. This study presents a computer-aided diagnosis system (CAD) that can predict hypertension prior to the systemic onset of the disease. This MRA-based CAD system is able to detect, track, and quantify the hypertension-related cerebrovascular alterations, then it makes a decision based on the analyzed data about whether each subject is at a high risk of developing hypertension or not. Such kind of prediction can help clinicians in taking proactive and preventative steps to stop the progress of the disease and mitigate adverse events

Using 3-D CNNs and Local Blood Flow Information to Segment Cerebral Vasculature

© 2018 IEEE. The variability of the strength (increase or decrease) of the blood flow signals throughout the range of slices of the MRA volume is a big challenge for any segmentation approach because it introduces more inhomogenities to the MRA data and hence less accuracy. In this paper, a novel cerebral blood vessel segmentation framework using Time-Of-Flight Magnetic Resonance Angiography (TOF-MRA) is proposed to handle this challenge. The segmentation framework is based on using three dimensional convolutional neural networks (3D-CNN) to segment the cerebral blood vessels taking into account the variability of blood flow signals throughout the MRA scans. It consists of the following two steps: i) bias field correction to handle intensity inhomogeneity which are caused by magnetic settings, ii)instead of constructing one CNN model for the whole TOF-MRA brain, the TOF-MRA volume is divided into two compartments, above Circle of Willis (CoW) and at and below CoW to account for blood flow signals variability across the MRA volume\u27s slices, then feed these two volumes into the three dimensional convolutional neural networks (3D-CNN). The final segmentation result is the combination of the output of each model. The proposed framework is tested on in-vivo data (30 TOF-MRA data sets). Both qualitative and quantitative validation with respect to ground truth (delineated by an MRA expert) are provided. The proposed approach achieved a high segmentation accuracy with 84.37% Dice similarity coefficient, sensitivity of 86.14%, and specificity of 99.00%